Blog favorite Dean Ashton has broken his ankle. I have to admit that as much as I think he's a fantastic player (and still under-rated), he's starting to build a Bellamy/Duff-like injury history.
Ashton was one of a few moderately priced strikers that has some history, a good team behind him, and favorable first-week match-ups. If you had him, or were considering him, alongside Berbatov and Sheva (this means you Jeremy) then you're probably in the market for Defoe, Saha, McCarthy or Harewood right about now.
Until it becomes clear who will partner Harewood - Zamora and Cole are the two most likely options with Sherringham remaining on the bench as a 20 minute reserve - there probably isn't an obvious West Ham replacement.